p16INK4A (CDKN2A) Rabbit Polyclonal Antibody

CAT#: TA301407

Rabbit Polyclonal Antibody against p14ARF



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

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经常一起买 (4)
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Recombinant protein of human cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1, 100 µg
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 2 ug/ml
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to a portion of human p14ARF (between residues 100-173). [Swiss-Prot# Q8N726]
Formulation Tris-glycine, 150mM NaCl and 0.05% sodium azide
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name cyclin-dependent kinase inhibitor 2A
Background The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1 alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF.
Synonyms ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4
Reference Data
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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