p16INK4A (CDKN2A) Rabbit Polyclonal Antibody
CAT#: TA301407
Rabbit Polyclonal Antibody against p14ARF
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CNY 300.00
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CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western Blot: 2 ug/ml |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide made to a portion of human p14ARF (between residues 100-173). [Swiss-Prot# Q8N726] |
Formulation | Tris-glycine, 150mM NaCl and 0.05% sodium azide |
Concentration | lot specific |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | cyclin-dependent kinase inhibitor 2A |
Database Link | |
Background | The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1 alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. |
Synonyms | ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer |
Documents
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