CD19

CD19 is a biomarker for B cell lineage and positively regulates mature B cell antigen receptor signal transduction cascade. CD19 has been used to diagnose diseases related to B-Cell Lymphomas, including Non-Hodgkin lymphomas (NHL), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). CD19 monoclonal antibody is widely studied for therapies of lymphoma, leukemia and autoimmune disorders, especially in the clinical trials of chimeric antigen receptor (CAR) T-cell therapy.

A schematic of an anti-CD19 CAR-expressing T-cell recognizing a CD19+ malignant cell. CAR, chimeric antigen receptor

CD19 UltraMab™ Antibody

IHC staining of FFPE human B-Cell Lymphoma using anti-CD19 mouse monoclonal antibody (SKU# UM500071; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120oC for 3min).

Flow cytometric analysis of viable B-Cell Lymphoma cell line (Raji) using anti-CD19 antibody at 1:20 (UM500071, red), compared to isotype control (anti-DDK TA180144, green), and negative control (PBS, blue).