Ptpn4 Mouse shRNA Plasmid (Locus ID 19258)

Specifications

Product Data
Product Name	Ptpn4 Mouse shRNA Plasmid (Locus ID 19258)
Locus ID	19258
UniProt ID	Q9WU22
Synonyms	hPTP-MEG; Ptn4; PTPMEG; TEP; TEP/mPTPMEG
Vector	pGFP-C-shLenti
Format	Lentiviral plasmids
Kit Components	Ptpn4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 19258). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq	NM_019933, NM_019933.1, NM_019933.2, BC140437
Summary	Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:17953619, PubMed:25825441). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed:18614237). May act at junctions between the membrane and the cytoskeleton.[UniProtKB/Swiss-Prot Function]
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed	OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.