Hdac4 Mouse shRNA Plasmid (Locus ID 208727)
CAT#: TL510852
Hdac4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 5,740.00
货期*
现货
规格
Cited in 1 publication. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | Hdac4 Mouse shRNA Plasmid (Locus ID 208727) |
Locus ID | 208727 |
UniProt ID | Q6NZM9 |
Synonyms | 4932408F19Rik; HD4 |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | Hdac4 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 208727). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | BC066052, NM_207225, NM_207225.1, NM_207225.2 |
Summary | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder
,Trazzi, S;Fuchs, C;Viggiano, R;De Franceschi, M;Valli, E;Jedynak, P;Hansen, FK;Perini, G;Rimondini, R;Kurz, T;Bartesaghi, R;Ciani, E;,
Hum. Mol. Genet.
,PubMed ID 27466189
[HDAC4]
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