NRXN3 Human shRNA Plasmid Kit (Locus ID 9369)

Specifications

Product Data
Product Name	NRXN3 Human shRNA Plasmid Kit (Locus ID 9369)
Locus ID	9369
UniProt ID	Q9Y4C0
Synonyms	C14orf60
Vector	pGFP-C-shLenti
Format	Lentiviral plasmids
Kit Components	NRXN3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9369). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq	NM_001105250, NM_001272020, NM_004796, NM_138970, NR_073546, NR_073547, NM_001330195, NM_004796.1, NM_004796.2, NM_004796.3, NM_004796.4, NM_004796.5, NM_138970.2, NM_138970.3, NM_138970.4, NM_001105250.1, NM_001105250.2, NM_001272020.1, BC059368, BC068469, BC142649, BC150194, BC152457, NM_001366425, NM_001366426, NR_158975, NR_158973, NR_158974, NM_001105250.3, NM_001272020.2, NM_138970.5, NM_004796.6
Summary	This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed	OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.