PVRL4 (NECTIN4) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) M1-S349
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.4
Note	Recombinant Human Poliovirus Receptor-Related Protein 4 is produced by human 293 cells. The target gene encoding Gly31-Ser349 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	81607
UniProt ID	Q96NY8
Synonyms	Nectin cell adhesion molecule 4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PVRL4; PRR4; LNIR
Summary	Nectin-4 (PVRL4) is a type I transmembrane glycoprotein that belongs to the nectin family of Ig superfamily proteins. Nectin-4 is expressed in the placenta, especially in endothelial cells. Nectin-4 ECD contains three Ig-like domains, including one N-terminal V-type and two C2-type. As cell adhesion molecules, Nectin-4 plays an important role in many biological processes during human development as well as adult life. Studies also showed that Nectin-4 acts as tumor-associated antigen in some of the breast, ovarian and non-small cell lung carcinomas, especially on those tumors with bad prognosis.
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Adherens junction

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