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CD19 Human Recombinant Protein
CAT＃: TP721367
PE Conjugated Human CD19 Protein (C-Fc)
View other "CD19" proteins (11)
|
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CNY 3,480.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence |
Glu21-Lys291
|
| Tag | C-Fc |
| Predicted MW | The protein has a predicted molecular weight of 56kDa and migrates at approximately 70-80kDa on SDS-PAGE with DTT-reduced condition before PE conjugation. |
| Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Purity | >90% |
| Conjugation | PE |
| Buffer | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Preparation | Affinity Protein A |
| Applications | FACS |
| Storage | An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles. |
| Stability | 6 Months |
| Bioactivity | PositiveThe definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test. |
| Reference Data | |
| RefSeq | P15391 |
| Locus ID | 930 |
| UniProt ID | P15391 |
| Summary | CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. |
| Protein Families | FACS |
| Protein Pathways | B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency |
Documents
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Resources
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400678 | CD19 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400678 | Transient overexpression lysate of CD19 molecule (CD19) |
CNY 3,080.00 |
|
| PH302922 | CD19 MS Standard C13 and N15-labeled recombinant protein (NP_001761) |
CNY 19,520.00 |
|
| TP302922 | Recombinant protein of human CD19 molecule (CD19), 20 µg |
CNY 2,900.00 |
|
| TP700276 | Purified recombinant protein of human CD19 molecule (CD19), transcript variant 2, with C-terminal Fc tag, expressed in human cells, 20 µg |
CNY 6,650.00 |
|
| TP700295 | Purified recombinant protein of human CD19 molecule (CD19), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg |
CNY 6,650.00 |
|
| TP721364 | Human CD19 Protein (C-Fc) |
CNY 2,450.00 |
|
| TP721365 | Human CD19 Protein (C-Fc-Avi) |
CNY 2,450.00 |
|
| TP721366 | Biotinylated Human CD19 Protein (C-Fc-Avi) |
CNY 3,480.00 |
|
| TP721368 | APC Conjugated Human CD19 Protein (C-Fc) |
CNY 3,480.00 |
|
| TP762435 | Purified recombinant protein of Human CD19 molecule (CD19), transcript variant 2, Gln314-End, with N-terminal His tag, expressed in E.coli, 50ug |
CNY 1,950.00 |
