FMRP (FMR1) (NM_002024) Human Recombinant Protein
CAT#: TP322699
Recombinant protein of human fragile X mental retardation 1 (FMR1), 20 µg
View other "FMRP" proteins (5)
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CNY 2,900.00
Cited in 7 publications. |
CNY 1,999.00
CNY 2,700.00
CNY 600.00
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC222699 representing NM_002024
Red=Cloning site Green=Tags(s) MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSR ANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQM CAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLE SSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLE FAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAP EEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYH LNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTS GTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTD NRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNG VP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 71 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_002015 |
Locus ID | 2332 |
UniProt ID | Q06787 |
Refseq Size | 4362 |
Cytogenetics | Xq27.3 |
Refseq ORF | 1896 |
Synonyms | FMRP; FRAXA; POF; POF1; POFX |
Summary | The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010] |
Protein Families | Druggable Genome |
Citations (7)
The use of this Proteins has been cited in the following citations: |
---|
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression
,null,
EMBO Molecular Medicine
,PubMed ID 35191199
[FMR1]
|
FMRP Levels in Human Peripheral Blood Leukocytes Correlates with Intellectual Disability
,null,
Diagnostics
,PubMed ID 34679478
[FMR1]
|
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
,Zhang, F;Kang, Y;Wang, M;Li, Y;Xu, T;,
Human Molecular Genetics
,PubMed ID 30107516
[FMR1]
|
Size and methylation mosaicism in males with Fragile X syndrome
,null,
Expert review of molecular diagnostics
,PubMed ID 28929824
[FMR1]
|
Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain
,null,
BMC Biology
,PubMed ID 28662698
[FMR1]
|
High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells
,null,
Stem Cells Translational Medicine
,PubMed ID 25999519
[FMR1]
|
FMRP and Myelin Protein Expression in Oligodendrocytes
,null,
Molecular and cellular neurosciences
,PubMed ID 23891804
[FMR1]
|
Documents
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Resources
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Other Versions
SKU | Description | Size | Price |
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LC419580 | FMR1 HEK293T cell transient overexpression lysate (as WB positive control) |
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LC434306 | FMR1 HEK293T cell transient overexpression lysate (as WB positive control) |
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LY419580 | Transient overexpression lysate of fragile X mental retardation 1 (FMR1) |
CNY 4,840.00 |
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LY434306 | Transient overexpression lysate of fragile X mental retardation 1 (FMR1), transcript variant ISO6 |
CNY 3,080.00 |
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PH322699 | FMR1 MS Standard C13 and N15-labeled recombinant protein (NP_002015) |
CNY 19,520.00 |