5 Lipoxygenase (ALOX5) (NM_000698) Human Recombinant Protein
CAT#: TP317259
Recombinant protein of human arachidonate 5-lipoxygenase (ALOX5), 20 µg
View other "5 Lipoxygenase" proteins (3)
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Avi-tag Biotinylated Protein Get a free quote |
CNY 2,900.00
Cited in 3 publications. |
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC217259 representing NM_000698
Red=Cloning site Green=Tags(s) MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRI EKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQ KQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEK IFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQG NIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLL AKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVV DIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYD WCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKP VKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 77.8 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000689 |
Locus ID | 240 |
UniProt ID | P09917 |
Refseq Size | 2568 |
Cytogenetics | 10q11.21 |
Refseq ORF | 2022 |
Synonyms | 5-LO; 5-LOX; 5LPG; LOG5 |
Summary | This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
Protein Families | Druggable Genome |
Protein Pathways | Arachidonic acid metabolism, Metabolic pathways |
Citations (3)
The use of this Proteins has been cited in the following citations: |
---|
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases
,null,
Cell Reports
,PubMed ID 28445728
[ALOX5]
|
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation *
,null,
The Journal of Biological Chemistry
,PubMed ID 26601954
[ALOX5]
|
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
,null,
Nature
,PubMed ID 26017313
[ALOX5]
|
Documents
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Resources
蛋白相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400234 | ALOX5 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
LY400234 | Transient overexpression lysate of arachidonate 5-lipoxygenase (ALOX5) |
CNY 4,840.00 |
|
PH317259 | ALOX5 MS Standard C13 and N15-labeled recombinant protein (NP_000689) |
CNY 19,520.00 |
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