5 Lipoxygenase (ALOX5) (NM_000698) Human Mass Spec Standard

CAT#: PH317259

ALOX5 MS Standard C13 and N15-labeled recombinant protein (NP_000689)



  View other "5 Lipoxygenase" proteins (3)

Need it in bulk or customized?
Get a free quote

CNY 19,520.00


货期*
4周

规格
    • 10 ug

Product images

经常一起买 (2)
Transient overexpression lysate of arachidonate 5-lipoxygenase (ALOX5)
    • 100 ug

CNY 4,840.00


ALOX5 mouse monoclonal antibody, clone OTI3F1
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description ALOX5 MS Standard C13 and N15-labeled recombinant protein (NP_000689)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217259
Predicted MW 77.8 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000689
RefSeq Size 2568
RefSeq ORF 2022
Synonyms 5-LO; 5-LOX; 5LPG; LOG5
Locus ID 240
Cytogenetics 10q11.21
Summary This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Protein Families Druggable Genome
Protein Pathways Arachidonic acid metabolism, Metabolic pathways
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...