Von Hippel Lindau (VHL) (NM_000551) Human Recombinant Protein
CAT#: TP316151
Recombinant protein of human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, 20 µg
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CNY 2,900.00
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Cited in 1 publication. |
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC216151 representing NM_000551
Red=Cloning site Green=Tags(s) MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSRE PSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSL NVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQR MGD TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 24 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Bioactivity | Binding assay (PMID: 27780863) |
Reference Data | |
RefSeq | NP_000542 |
Locus ID | 7428 |
UniProt ID | P40337 |
Refseq Size | 2968 |
Cytogenetics | 3p25.3 |
Refseq ORF | 639 |
Synonyms | HRCA1; pVHL; RCA1; VHL1 |
Summary | Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Protein 4.1 R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation
,Huang, SC;Zhou, A;Nguyen, DT;Zhang, HS;,
Journal of Biological Chemistry
,PubMed ID 27780863
[VHL]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400188 | VHL HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC404985 | VHL HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400188 | Transient overexpression lysate of von Hippel-Lindau tumor suppressor (VHL), transcript variant 1 |
CNY 3,080.00 |
|
LY404985 | Transient overexpression lysate of von Hippel-Lindau tumor suppressor (VHL), transcript variant 2 |
CNY 3,080.00 |
|
PH316151 | VHL MS Standard C13 and N15-labeled recombinant protein (NP_000542) |
CNY 19,520.00 |
|
TP760451 | Purified recombinant protein of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
CNY 2,040.00 |
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