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Shugoshin (SGO1) (NM_001012411) Human Recombinant Protein
CAT＃: TP313965
Recombinant protein of human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B1, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC213965 representing NM_001012411
Red=Cloning site Green=Tags(s) MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALEN EKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQ IPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSATPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSP KKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKSMKQIQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 31.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001012411 |
| Locus ID | 151648 |
| UniProt ID | Q5FBB7 |
| Refseq Size | 1200 |
| Cytogenetics | 3p24.3 |
| Refseq ORF | 825 |
| Synonyms | CAID; NY-BR-85; SGO; SGOL1 |
| Summary | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
| Protein Pathways | Oocyte meiosis |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC408583 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC422848 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC422849 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC422850 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC422851 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY408583 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C2 |
CNY 3,080.00 |
|
| LY422848 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A2 |
CNY 4,840.00 |
|
| LY422849 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B1 |
CNY 3,080.00 |
|
| LY422850 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B2 |
CNY 3,080.00 |
|
| LY422851 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C1 |
CNY 3,080.00 |
|
| PH313965 | SGOL1 MS Standard C13 and N15-labeled recombinant protein (NP_001012411) |
CNY 14,250.00 |
|
| PH316188 | SGOL1 MS Standard C13 and N15-labeled recombinant protein (NP_001012413) |
CNY 19,520.00 |
|
| TP316188 | Recombinant protein of human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C1, 20 µg |
CNY 2,900.00 |
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