SIVA (SIVA1) (NM_006427) Human Mass Spec Standard

Specifications

Product Data
Description	SIVA1 MS Standard C13 and N15-labeled recombinant protein (NP_006418)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC215680
Predicted MW	18.5 kDa
Protein Sequence	Sequence Link (showhide) >RC215680 representing NM_006427 Red=Cloning site Green=Tags(s) MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPES PKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVR TCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006418
RefSeq Size	751
RefSeq ORF	525
Synonyms	CD27BP; SIVA; Siva-1; Siva-2
Locus ID	10572
Cytogenetics	14q32.33
Summary	This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Protein Families	Druggable Genome

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