RBM38 (NM_183425) Human Mass Spec Standard

Specifications

Product Data
Description	RBM38 MS Standard C13 and N15-labeled recombinant protein (NP_906270)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC211451
Predicted MW	12.7 kDa
Protein Sequence	Sequence Link (showhide) >RC211451 representing NM_183425 Red=Cloning site Green=Tags(s) MLLQPAPCAPSAGFPRPLAAPGAMHGSQKDTTFTKIFVGGLPYHTTDASLRKYFEGFGDIEEAVVITDRQ TGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRSLQTG TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_906270
RefSeq Size	2346
RefSeq ORF	363
Synonyms	dJ800J21.2; HSRNASEB; RNPC1; SEB4B; SEB4D
Locus ID	55544
Cytogenetics	20q13.31
Summary	RNA-binding protein that specifically bind the 3' UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.[UniProtKB/Swiss-Prot Function]

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