KCTD11 (NM_001002914) Human Mass Spec Standard

CAT#: PH305782

KCTD11 MS Standard C13 and N15-labeled recombinant protein (NP_001002914)



  View other "KCTD11" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of potassium channel tetramerisation domain containing 11 (KCTD11)
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Rabbit Polyclonal Anti-KCTD11 Antibody
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Specifications

Product Data
Description KCTD11 MS Standard C13 and N15-labeled recombinant protein (NP_001002914)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205782
Predicted MW 25.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001002914
RefSeq Size 3081
RefSeq ORF 696
Synonyms C17orf36; KCASH1; REN; REN/KCTD11
Locus ID 147040
Cytogenetics 17p13.1
Summary Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.[UniProtKB/Swiss-Prot Function]
Protein Families Ion Channels: Other
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