DR1 (NM_001938) Human Mass Spec Standard

Specifications

Product Data
Description	DR1 MS Standard C13 and N15-labeled recombinant protein (NP_001929)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205733
Predicted MW	19.4 kDa
Protein Sequence	Sequence Link (showhide) >RC205733 protein sequence Red=Cloning site Green=Tags(s) MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEH VIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQE WLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001929
RefSeq Size	3222
RefSeq ORF	528
Synonyms	NC2; NC2-BETA; NC2B; NCB2
Locus ID	1810
Cytogenetics	1p22.1
Summary	This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
Protein Families	Transcription Factors

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