PGP9.5 (UCHL1) (NM_004181) Human Mass Spec Standard

Specifications

Product Data
Description	UCHL1 MS Standard C13 and N15-labeled recombinant protein (NP_004172)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201803
Predicted MW	24.8 kDa
Protein Sequence	Sequence Link (showhide) >RC201803 protein sequence Red=Cloning site Green=Tags(s) MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEEL KGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQ AAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQG EVRFSAVALCKAA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004172
RefSeq Size	1141
RefSeq ORF	669
Synonyms	HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1
Locus ID	7345
Cytogenetics	4p13
Summary	The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Protein Families	Druggable Genome, Protease
Protein Pathways	Parkinson's disease

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