NFkB p100 / p52 (NFKB2) (NM_001077493) Human Mass Spec Standard

CAT#: PH301147

NFKB2 MS Standard C13 and N15-labeled recombinant protein (NP_001070961)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (NFKB2), transcript variant 2
    • 100 ug

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Specifications

Product Data
Description NFKB2 MS Standard C13 and N15-labeled recombinant protein (NP_001070961)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC201147
Predicted MW 96.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001070961
RefSeq Size 3416
RefSeq ORF 2697
Synonyms LYT-10; LYT10; p52
Locus ID 4791
Cytogenetics 10q24.32
Summary This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Protein Families Transcription Factors
Protein Pathways MAPK signaling pathway, Pathways in cancer
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