Il17rc Mouse Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	Il17rc
Locus ID	171095
Kit Components	KN308241G1, Il17rc gRNA vector 1 in pCas-Guide CRISPR vector KN308241G2, Il17rc gRNA vector 2 in pCas-Guide CRISPR vector KN308241LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_134159, NM_178942
Synonyms	1110025H02Rik; Gm19850; IL-17RC; IL17-RC; IL17-RL; Il17rl
Summary	Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:17911633, PubMed:20554964). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity).[UniProtKB/Swiss-Prot Function]

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