Sodium bicarbonate transporter like protein 11 (SLC4A11) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	Sodium bicarbonate transporter like protein 11
Locus ID	83959
Kit Components	KN222743G1, Sodium bicarbonate transporter like protein 11 gRNA vector 1 in pCas-Guide CRISPR vector KN222743G2, Sodium bicarbonate transporter like protein 11 gRNA vector 2 in pCas-Guide CRISPR vector KN222743BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001174089, NM_001174090, NM_032034, NR_135000, NM_001363745
Synonyms	BTR1; CDPD1; CHED2; dJ794I6.2; NABC1
Summary	This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

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