Caspase 8 (CASP8) Human Gene Knockout Kit (CRISPR)
CAT#: KN216248RB
CASP8 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 3,656.00
CNY 4,370.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | Caspase 8 |
Locus ID | 841 |
Kit Components |
KN216248G1, Caspase 8 gRNA vector 1 in pCas-Guide CRISPR vector KN216248G2, Caspase 8 gRNA vector 2 in pCas-Guide CRISPR vector KN216248RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001080124, NM_001080125, NM_001228, NM_033355, NM_033356, NM_033357, NM_033358, NR_111983 |
Synonyms | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 |
Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN216248 | CASP8 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN216248BN | CASP8 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN216248LP | CASP8 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN416248 | CASP8 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA100594 | CASP8 CRISPRa kit - CRISPR gene activation of human caspase 8 |
CNY 12,255.00 |
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