PACE4 (PCSK6) Human Gene Knockout Kit (CRISPR)
CAT#: KN213553RB
PCSK6 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 7,144.00
CNY 9,690.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | PACE4 |
Locus ID | 5046 |
Kit Components |
KN213553G1, PACE4 gRNA vector 1 in pCas-Guide CRISPR vector KN213553G2, PACE4 gRNA vector 2 in pCas-Guide CRISPR vector KN213553RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001291309, NM_002570, NM_138319, NM_138320, NM_138321, NM_138322, NM_138323, NM_138324, NM_138325 |
Synonyms | PACE4; SPC4 |
Summary | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014] |
Documents
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Resources
基因表达相关资源 |
Other Versions
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KN213553 | PCSK6 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
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KN213553BN | PCSK6 - human gene knockout kit via CRISPR, HDR mediated |
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KN213553LP | PCSK6 - human gene knockout kit via CRISPR, HDR mediated |
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KN413553 | PCSK6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
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GA103368 | PCSK6 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 6 |
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