Heme Oxygenase 1 (HMOX1) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	Heme Oxygenase 1
Locus ID	3162
Kit Components	KN200463G1, Heme Oxygenase 1 gRNA vector 1 in pCas-Guide CRISPR vector KN200463G2, Heme Oxygenase 1 gRNA vector 2 in pCas-Guide CRISPR vector KN200463LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_002133
Synonyms	bK286B10; HMOX1D; HO-1; HSP32
Summary	Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

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