Mouse Nova1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nova1
Locus ID	664883
Kit Components	GA218310G1, Nova1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA218310G2, Nova1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA218310G3, Nova1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_021361, NM_001364634, NM_001364635, NM_001364636, NM_001364637, NM_001364638, NM_001364639
Synonyms	9430099M15Rik; G630039L02; Nova-1
Summary	Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer.[UniProtKB/Swiss-Prot Function]

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