Mouse Spag8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Spag8
Locus ID	433700
Kit Components	GA217575G1, Spag8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA217575G2, Spag8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA217575G3, Spag8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001007463, NM_001290462
Synonyms	MH-SPAG8; SMP-1
Summary	Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (PubMed:20488182). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (PubMed:17187156). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity).[UniProtKB/Swiss-Prot Function]

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