Mouse Nalcn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nalcn
Locus ID	338370
Kit Components	GA216937G1, Nalcn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216937G2, Nalcn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216937G3, Nalcn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_177393, NM_177754
Synonyms	A530023G15Rik; AI849508; Vgcnl1
Summary	Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions (PubMed:17448995). Regulates the resting membrane potential and controls neuronal excitability. Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway (PubMed:19092807). In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs (PubMed:19092807, PubMed:19575010, PubMed:21040849). Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration (PubMed:21177381). NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal (PubMed:22508057). Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (PubMed:27177420).[UniProtKB/Swiss-Prot Function]

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