Mouse Xpnpep3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Xpnpep3
Locus ID	321003
Kit Components	GA216602G1, Xpnpep3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216602G2, Xpnpep3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216602G3, Xpnpep3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001347075, NM_177310
Synonyms	APP3; E430012M05Rik
Summary	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.[UniProtKB/Swiss-Prot Function]

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