Mouse Pank4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pank4
Locus ID	269614
Kit Components	GA216025G1, Pank4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA216025G2, Pank4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA216025G3, Pank4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001305804, NM_172990, NR_131230
Synonyms	D030031I12Rik; R75150
Summary	Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway (By similarity). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (By similarity). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (By similarity).[UniProtKB/Swiss-Prot Function]

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