Mouse Gpr75 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gpr75
Locus ID	237716
Kit Components	GA214740G1, Gpr75 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214740G2, Gpr75 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214740G3, Gpr75 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175490
Summary	G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.[UniProtKB/Swiss-Prot Function]

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