Mouse Lingo1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lingo1
Locus ID	235402
Kit Components	GA214621G1, Lingo1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214621G2, Lingo1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214621G3, Lingo1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001311076, NM_181074, NM_001361115, NM_001361116, NM_001361117, NM_001361118, NM_001361119, NM_001361120
Synonyms	4930471K13Rik; AV148400; LERN1; LINGO-1; Lrrn6a; UNQ201
Summary	Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.[UniProtKB/Swiss-Prot Function]

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