Mouse Atg4d activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Atg4d
Locus ID	235040
Kit Components	GA214592G1, Atg4d gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214592G2, Atg4d gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214592G3, Atg4d gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_153583
Synonyms	9830134P12Rik; APG4-D; Apg4d; Atg4dl; Autl4
Summary	Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.[UniProtKB/Swiss-Prot Function]

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