Mouse Trafd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trafd1
Locus ID	231712
Kit Components	GA214285G1, Trafd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214285G2, Trafd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214285G3, Trafd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163470, NM_172275, NM_001359947
Synonyms	1110008K06Rik; Fln29
Summary	Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.[UniProtKB/Swiss-Prot Function]

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