Mouse Cipc activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cipc
Locus ID	217732
Kit Components	GA213498G1, Cipc gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213498G2, Cipc gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213498G3, Cipc gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001289429, NM_001289430, NM_001289431, NM_001289432, NM_173735, NR_033623, NM_001364274
Synonyms	2310044G17Rik; AI842544; AI853744; Kiaa1737; mKIAA1737
Summary	Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601). However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660).[UniProtKB/Swiss-Prot Function]

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