Mouse Ccm2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ccm2
Locus ID	216527
Kit Components	GA213359G1, Ccm2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213359G2, Ccm2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213359G3, Ccm2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190343, NM_001190344, NM_146014
Synonyms	BC029157
Summary	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.[UniProtKB/Swiss-Prot Function]

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