Mouse Wdr5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wdr5
Locus ID	140858
Kit Components	GA212540G1, Wdr5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212540G2, Wdr5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212540G3, Wdr5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_080848
Synonyms	2410008O07Rik; AA408785; AA960360; Big; Big-3
Summary	Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).[UniProtKB/Swiss-Prot Function]

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