Mouse Scaf8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scaf8
Locus ID	106583
Kit Components	GA211938G1, Scaf8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211938G2, Scaf8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211938G3, Scaf8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_134123
Synonyms	A630086M08Rik; A930036P18Rik; AA408306; AI447644; AI448652; AU015035; mKIAA1116; Rbm16
Summary	Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.[UniProtKB/Swiss-Prot Function]

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