Mouse Hcar2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hcar2
Locus ID	80885
Kit Components	GA211147G1, Hcar2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211147G2, Hcar2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211147G3, Hcar2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_030701
Synonyms	Gpr109a; Gpr109b; HM74; mHM74b; Niacr1; PUMA-G; Pumag
Summary	Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.[UniProtKB/Swiss-Prot Function]

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