Mouse Il33 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il33
Locus ID	77125
Kit Components	GA210715G1, Il33 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210715G2, Il33 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210715G3, Il33 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164724, NM_133775, NM_001360725
Synonyms	9230117N10Rik; Il-33; Il1f11; NF-HEV
Summary	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.[UniProtKB/Swiss-Prot Function]

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