Mouse Clasp1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Clasp1
Locus ID	76707
Kit Components	GA210586G1, Clasp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210586G2, Clasp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210586G3, Clasp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001081276, NM_001293300, NM_001293301, NM_029709, NM_177548, NM_001359328, NM_001359329, NM_001359330, NM_001359331, NM_001359334, NM_001359335, NM_001359336, NM_001359337, NM_001359338, NM_001359339, NM_001359340, NM_001359341, NM_001359342, NM_001359343, NM_001359345, NM_001359346, NM_001359347
Synonyms	1700030C23Rik; 5730583A19Rik; B130045P17Rik; mKIAA0622
Summary	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).[UniProtKB/Swiss-Prot Function]

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