Mouse Cenpu activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cenpu
Locus ID	71876
Kit Components	GA208991G1, Cenpu gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208991G2, Cenpu gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208991G3, Cenpu gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_027973, NM_001368403
Synonyms	1700029A22Rik; Mlf1ip
Summary	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).[UniProtKB/Swiss-Prot Function]

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