Mouse Ankle2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ankle2
Locus ID	71782
Kit Components	GA208945G1, Ankle2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208945G2, Ankle2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208945G3, Ankle2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001253814, NM_027922
Synonyms	1110001J12Rik; AI661024; D5Ertd585e
Summary	Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity).[UniProtKB/Swiss-Prot Function]

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