Mouse Spdya activation kit by CRISPRa

CAT#: GA208656

Spdya CRISPRa kit - CRISPR gene activation of mouse speedy/RINGO cell cycle regulator family, member A



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Spdya
Locus ID 70891
Kit Components

GA208656G1, Spdya gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA208656G2, Spdya gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA208656G3, Spdya gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001142631, NM_029254
Synonyms 4921517J08Rik; 4930548B21Rik; GS4; MLZ-465; Spdy1
Summary Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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