Mouse Carmil1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Carmil1
Locus ID	68732
Kit Components	GA207910G1, Carmil1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207910G2, Carmil1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207910G3, Carmil1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001311122, NM_026825, NM_177807
Synonyms	1110037D04Rik; AI425970; CARMIL; CARML1; D130057M20; Lrrc16; Lrrc16a
Summary	Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:16054028).[UniProtKB/Swiss-Prot Function]

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