Mouse Rnf166 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnf166
Locus ID	68718
Kit Components	GA207905G1, Rnf166 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207905G2, Rnf166 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207905G3, Rnf166 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033142, NM_001368370
Synonyms	1110031E24Rik; AW555115; Zfp313l
Summary	E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Plays also a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication.[UniProtKB/Swiss-Prot Function]

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