Mouse Tab2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tab2
Locus ID	68652
Kit Components	GA207884G1, Tab2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207884G2, Tab2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207884G3, Tab2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_138667, NM_001359534
Synonyms	1110030N06Rik; A530078N03Rik; Map3k7ip2; mKIAA0733
Summary	Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).[UniProtKB/Swiss-Prot Function]

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