Mouse Kmt5a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kmt5a
Locus ID	67956
Kit Components	GA207610G1, Kmt5a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207610G2, Kmt5a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207610G3, Kmt5a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310723, NM_001310725, NM_001310727, NM_030241
Synonyms	2410195B05Rik; AA617402; AW536475; PR-SET7; PR/SET07; Setd8
Summary	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration (By similarity).[UniProtKB/Swiss-Prot Function]

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