Mouse Rassf7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rassf7
Locus ID	66985
Kit Components	GA207065G1, Rassf7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207065G2, Rassf7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207065G3, Rassf7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025886
Synonyms	2400009B11Rik; AW210608
Summary	Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (By similarity).[UniProtKB/Swiss-Prot Function]

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