Mouse Zmynd11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zmynd11
Locus ID	66505
Kit Components	GA206817G1, Zmynd11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206817G2, Zmynd11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206817G3, Zmynd11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001199141, NM_001347470, NM_001347471, NM_001347472, NM_001347473, NM_001347474, NM_001347476, NM_001347477, NM_001347479, NM_001347480, NM_001347481, NM_144516
Synonyms	2210402G22Rik; BS69
Summary	Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage (PubMed:24590075). Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (PubMed:24590075).[UniProtKB/Swiss-Prot Function]

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