Mouse Zmynd11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zmynd11
Locus ID	66505
Kit Components	GA206817G1, Zmynd11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206817G2, Zmynd11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206817G3, Zmynd11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001199141, NM_001347470, NM_001347471, NM_001347472, NM_001347473, NM_001347474, NM_001347476, NM_001347477, NM_001347479, NM_001347480, NM_001347481, NM_144516
Synonyms	2210402G22Rik; BS69
Summary	Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage (PubMed:24590075). Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth (PubMed:24590075).[UniProtKB/Swiss-Prot Function]

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