Mouse Map3k20 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Map3k20
Locus ID	65964
Kit Components	GA206531G1, Map3k20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206531G2, Map3k20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206531G3, Map3k20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164791, NM_023057, NM_178084
Synonyms	AV006891; B230120H23Rik; MLTK; MLTKalpha; MLTKbeta; Zak
Summary	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways (PubMed:11042189). Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14 (By similarity). Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (By similarity). Involved in limb development (PubMed:26755636).[UniProtKB/Swiss-Prot Function]

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