Mouse Il17re activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il17re
Locus ID	57890
Kit Components	GA206236G1, Il17re gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206236G2, Il17re gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206236G3, Il17re gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001034029, NM_001034031, NM_145826, NM_001362204, NM_001362205
Synonyms	AA589509; IL-17RE; Il25r
Summary	Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.[UniProtKB/Swiss-Prot Function]

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